Health

Rare mutation hints gene editing could prevent Alzheimer’s disease

Two people with a mutant version of a gene variant – APOE4 – linked to Alzheimer’s showed no signs of dementia, indicating that gene editing to mimic the effect may work against the condition

By Jason Arunn Murugesu

19 September 2023

Scientist examining DNA results on a screen — DNA tests results can reveal if we have genes that make us more or less likely to get certain medical conditions
ABO/TEK IMAGE/SPL

Reducing the activity of a high-risk gene variant for Alzheimer’s disease might one day help prevent or slow down the progress of the condition.

There are three variants of the apolipoprotein E (APOE) gene, which is involved in making a protein that helps carry cholesterol around the body. One variant, APOE4, is the biggest known genetic risk factor for Alzheimer’s disease.

Possessing a single copy, or allele, of APOE4 more than doubles the risk…