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Health

CAR T-cell therapy could help prevent clogged arteries

Not everyone responds to statins, the standard treatment for people at risk of cardiovascular disease, so an alternative based on genetically engineered immune cells could help prevent arteries from becoming blocked with plaque

By Carissa Wong

11 February 2025

A build-up of plaque in arteries can lead to cardiovascular conditions

SEBASTIAN KAULITZKI/SCIENCE PHOTO LIBRARY

Genetically engineered immune cells could help reduce the clogging of arteries, potentially lowering the risk of heart attack or stroke in people who don’t respond to common treatments.

Doctors often treat those at high risk of these conditions using drugs called statins, but they don’t protect everyone. “If statins were perfect we wouldn’t have such an issue with cardiovascular disease – it’s still the leading cause of death worldwide,“ says Robert Schwab at the University of Pennsylvania.

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