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Men with extra X chromosome father normal children

By Sylvia Pagán Westphal

22 June 2002

SEVERAL men with a serious genetic fault have been able to father normal children thanks to the controversial IVF technique known as ICSI.

Men with Klinefelter’s syndrome have an extra X chromosome. While many don’t know about the condition until they discover they’re infertile, others have symptoms such as mental retardation. Since the men cannot produce viable sperm, for the past few years Zev Rosenwaks’s team at Cornell University has been retrieving immature sperm directly from their testicles. The best-looking ones are used to fertilise eggs from their partners using ICSI, or intracytoplasmic sperm injection, in which a sperm is injected into the egg.…

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