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WE ALL have to die. But when the time comes, will it be because we were born with the wrong genes, grew up in poverty, or spent our adult lives smoking, eating too much and exercising too little?

Chances are it will be a combination of genetics and environmental influences: teasing them apart is one of science’s great challenges. We want to know how genes interact with the environment, and use that knowledge to prevent disease and premature death.

In the coming weeks, researchers in the UK will take a big step towards meeting this challenge. After five years of…

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