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Health

Single RNA jab adjusts blood cholesterol

By Andy Coghlan

29 March 2006

IF YOU suffered from high cholesterol and were offered a single injection guaranteed to halve your blood cholesterol within hours, would you accept it? That scenario is a step closer, following a major success with a technique called RNA interference reported this week.

RNAi allows disease-causing genes to be switched off at will by interfering with a cell’s RNA, giving it huge clinical potential. The difficulty so far has been in finding ways to get RNAi-based therapies into cells.

Now a team led by Ian MacLachlan of the Canadian company Protiva Biotherapeutics in Burnaby, British Columbia, has used RNAi in…

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