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Sex differences run deeper than we think

12 July 2006

MEN and women often appear to be poles apart. Now it seems we really can blame our genes. In mice, at least, it appears that many thousands of genes are expressed differently in the two sexes, far more than suspected.

“More than half the genes are different between genders, an order of magnitude more than previously thought,” says Xia Yang, head of the team at the University of California, Los Angeles, that compared gene expression in four different tissues in male and female mice.

The team profiled a total of 23,574 genes from 334 mice. In fat, liver and muscle,…

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