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Life

Longevity gene keeps the brain ticking over

By Andy Coghlan

11 June 2008

New Scientist. Science news and long reads from expert journalists, covering developments in science, technology, health and the environment on the website and the magazine.

A GENE linked to IQ might also help to prolong life.

The gene codes for an enzyme called succinic semialdehyde dehydrogenase (SSADH), which destroys GABA, a neurotransmitter that dampens brain activity and causes drowsiness. The gene comes in two common forms: the so-called “T” version is 20 per cent less efficient than the “C” version. In previous studies, young people with two copies of the T version performed slightly worse on IQ tests.

SSADH also detoxifies the brain by getting rid of excess acid, helping to protect cells from the free-radical damage that accelerates ageing.

So to study the effects…

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