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Eternal sunshine of the spotless mouse mind

29 October 2008

FOR those haunted by thoughts of an accident or ill-fated love affair, erasing these memories might be tempting. This ability could be a step closer after the successful wiping of a painful memory from the minds of mice.

Joe Tsien at the Medical College of Georgia, Augusta, and colleagues trained mice to have a painful memory by giving them a mild electric shock while placing them in a particular chamber and playing a specific noise. Shortly after boosting levels of the protein alpha-CaMKII, which is involved in memory storage and retrieval, the mice were returned to the chamber and…

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