A SAFER way to give drugs to prevent blindness might be to break through the blood-retina barrier that normally prevents molecules in the blood from reaching the retina. At the moment, such drugs have to be regularly injected into the eyeball. This can cause eye infections and even blindness in 1 in 50 cases.
A team led by Matthew Campbell at Trinity College in Dublin, Ireland, has now restored the vision of mice by temporarily weakening this barrier, to let drug molecules injected into the blood slip through. They used a technique called RNA interference (RNAi) to block the production…
