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Health

Serotonin cell discoveries mean rethink of depression

By Linda Geddes

21 July 2010

New Scientist. Science news and long reads from expert journalists, covering developments in science, technology, health and the environment on the website and the magazine.

What’s behind your anxiety?

(Image: Nathan Lau/Design Pics Inc./Rex Features)

IF YOU thought depression was caused by low serotonin levels, think again. It looks as if the brain chemistry of a depressed person is much more complex, with mounting evidence suggesting that too much serotonin in some brain regions is to blame.

If correct, it might explain some of the negative side-effects associated with selective serotonin re-uptake inhibitors (SSRIs), antidepressants like Prozac which increase the amount of the neurotransmitter serotonin in some parts of the brain.

The traditional view of depression was largely based on the observation that SSRIs boost…

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